产品描述
| 熔点 | 155-156°C |
| 敏感性 | 对光和空气敏感 |
| 存贮条件 | 充氩保存 |
| 应用 | A sodium channel blocker and DNA methylation inhibitor |
| 产品介绍 | Procaine HCl是一种钠离子通道的，NMDA受体以及乙酰胆碱受体抑制剂， IC50分别为60 μM， 0.296 mM何45.5 μM，也是一种，5-HT3抑制剂，KD为1.7 μM。 |
| 生化机理 | Procaine hydrochloride is a salt of the compound Procaine. Procaine is a noted sodium channel blocker with a variety of inhibitory effects. In skeletal muscle, Procaine has been reported to inhibit calcium-induced calcium release (CICR). Procaine is also noted to act as a DNA methylation inhibitor and to cause demethylation and reactivation of methylation-silenced genes such as RARβ and GSTP1. WIF-1 is noted to be reactivated in a cancer cell line and to downregulate the Wnt canonical pathway. In studies utilizing a neuroblastoma cell line (SHEP), Procaine is reported to induce neuronal apoptosis in a manner correlated with lipid solubility of the compound. In an adult mouse muscle cell line (HEK293), the presence of procaine is reported to potently inhibit nicotinic acetylcholine receptors. Procaine is available alone and in its salt form as Procaine HCl . |
| 别名 | 普鲁卡因盐酸盐;4-氨基苯甲酸-2-（二乙氨基）乙酯盐酸;2-(二乙氨基)乙基4-氨基苯甲酸酯盐酸盐;对氨基苯甲酸-2-二乙胺基乙酯盐酸盐;2-二乙基氨基乙基4-氨基苯甲酸酯盐酸盐;奴佛卡因盐酸盐4-Aminobenzoic acid 2-diethylaminoethyl ester;p-Aminobenzoic acid diethylaminoethyl ester hydrochloride;Novocaine hydrochloride2-Diethylaminoethyl 4-Aminobenzoate Hydrochloride |
