产品描述
| 敏感性 | 热敏感 |
| 溶解性 | Soluble in water with heating and/or sonication |
| 存贮条件 | 储存温度 2-8°C； 充氩保存 |
| 应用 | A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines |
| 产品介绍 | Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin , the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin or Carboplatin , and shows antitumor activity in cell lines with acquired Cisplatin resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently. |
| 生化机理 |
Oxaliplatin is a platinum-based antineoplastic agent that is used in cancer chemotherapy. Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin forms platinum-DNA adducts. Oxaliplatin causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. |
| 别名 | (反-1,2-环己烷二胺)草酸铂(II)；奥利沙铂；[SP-4-2-（1R-反式）] -（1，2-环己二胺-N，N′）[乙二酸（2-）-O，O’]铂；;(trans-1,2-Cyclohexanediamine)oxalatoplatinum(II);[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum |
