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产品描述
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in DMSO(warmed) (>2 mg/ml). |
| 存贮条件 | 储存温度2-8℃ |
| 密度 | 1.4170 |
| 应用 | An inhibitor of GSK-3β and cyclin-dependent kinases. |
| 产品介绍 | Indirubin, also known as isoindigotin, is an inhibitor of cyclin-dependent kinases (CDK1/cyclin B (IC50 = 10μM), CDK2/cyclin A (IC50 = 2.2μM), CDK2/cyclin E (IC50 = 7.5μM), CDK4/cyclin D1 (IC50 = 12μM), CDK5/p35 (IC50 = 5.5μM)) and of GSK-3β (IC50 = 600nM). Studies investigating functional isoindigos show that they have the ability to disrupt cell growth and proliferation. The compound is a potent aryl hydrocarbon receptor ligand and is found in human urine and fetal bovine serum. Synthesized isoindigo-based oligothiophenes are used to study heterojunction solar cells. Shown to inhibit allergic contact dermatitis by regulating T helper mediated immune system in a DNCB-induced model. |
| 别名 | 靛红Indigo Red;Isoindogotin |
