产品描述
| 应用 |
N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine has been used: · in the treatment of human embryonic kidney (HEK293T) cells for assessing its effect on the Jembrana disease virus (JDV) viral infectivity factor (Vif) functionality · in P19 embryonic carcinoma cells for chelation of zinc ions released during apoptosis · to evaluate its effect on lentiviral Vpx infection on human monocytic THP-1 cells |
| 生化机理 | N,N,N′,N′-Tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) elicits pro-apoptotic effect in human acute promyelocytic NB4 cells by inhibiting nitric oxide signalling and Zn2+ signaling.[1] In microglia pretreated with zinc, TPEN inhibits the interleukin 6 secretion and nitric oxide synthase (iNOS) mRNA expression.[2] It induces damage on DNA structure by activating ATM (ataxia telangiectasia mutated) and ATR (ATM-Rad3-related) signaling in human colon cancer cells. TPEN是一种可透过膜的锌螯合剂；可降低细胞内锌水平并诱导细胞凋亡（即细胞收缩和凋亡小体的形成、DNA片段化和形成典型的DNA梯状带）。 |
| 别名 | ;TPEN;TPEDA |
