产品描述
| 溶解性 | DMSO: 2 mg/mL, clear (warmed) |
| 存贮条件 | 储存温度-20°C |
| 应用 | II型Bcr-Abl抑制剂 |
| 产品介绍 | GNF-7 抑制 Bcr-Abl WT 和 Bcr-Abl T315I, IC50 分别为133 nM 和 61 nM。 |
| 生化机理 | GNF-7 is a multi-targeted kinase inhibitor that inhibits RAS signaling in addition to inhibiting the T315I “Gatekeeper” mutant of Bcr-Abl. GNF-7 inhibits NRAS-dependent cells in pre-clinical models of AML and ALL and inhibited T315I-Bcr-Abl dependent tumor growth in a murine model of CML. |
| 别名 | ;N-(4-Methyl-3-(1-methyl-7-(6-methylpyridin-3-ylamino)-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)phenyl)-3-(trifluoromethyl)benzamide; N-[3-[1,4-Dihydro-1-methyl-7-[(6-methyl-3-pyridinyl)amino]-2-oxopyrimido[4,5-d]pyrimidin-3(2H)-yl]-4-methylphenyl]-3-(trifluoromethyl)-benzamide |
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