产品描述
| 应用 |
WAY-100635 maleate salt has been used as a 5-HT1A serotonin receptor antagonist: · to study whether the behavior of the cleaner wrasse is regulated by serotonin activity · to block activity of 3,4 methylenedioxymethamphetamine (MDMA) used to induce oxytocin release in male Wistar rats to increase their social behavior · to study the role of serotonin during metamorphosis of the ascidian Phallusia mammillata larvae |
| 产品介绍 | WAY-100635马来酸盐是5-HT受体拮抗剂，IC50为0.95nM |
| 生化机理 | WAY-100635 maleate salt is a potent, selective and high affinity SR-2B antagonist with a pIC50 of 10.4. The affinity (pKi) of WAY-100635 maleate salt for tSR-2B is 9.5. In addition, WAY-100635 maleate salt also blocks serotonin-evoked contraction of rat isolated stomach fundus. |
| 别名 | N- [2- [4-（2-甲氧基苯基）-1-哌嗪基] 乙基]-N-2-吡啶基环己基甲酰胺 马来酸盐;N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt |
