产品描述
| 熔点 | 43 - 47°C |
| 敏感性 | 对热敏感 |
| 溶解性 | Soluble in DMSO (19 mg/mL), ethanol (20 mg/mL), and DMF (20 mg/mL). |
| 存贮条件 | 贮存温度-20°C，充氩保存 |
| 应用 | Orlistat是一种通用的脂肪酶抑制剂，作用于人体十二指肠液的PL，IC50为122 ng/ml。 |
| 产品介绍 | Lipase Inhibitor, THL (Tetrahydrolipstatin), is a compound that has been shown to rapidly inactivate lipoprotein lipase (LPL). This agent has been found to bind both subunits of LPL, induce tetramerisation, and cause local conformational changes. The exception to lipase inhibition capacities of THL is phospholipase A2, which is not affected by THL. Mechanistic studies suggest that THL inhibits the thioesterase domain of fatty acid synthase (FAS) and as a result halts cell proliferation and causes cell apoptosis. More detailed experiments show that gradually THL affects the retinoblastoma protein pathway and leads to cell-cycle arrest at G1/S boundary. Lipase Inhibitor, THL is an inhibitor of pancreatic and gastric lipase, as well as carboxyl ester lipase (CEL) and diacylglycerol lipase-α (DAGLα). Lipase Inhibitor, THL also activates caspase-3. |
| 生化机理 | 奥利司他用于肥胖症研究，是一种胰脂肪酶抑制剂，在胃肠道局部起作用以抑制脂肪酶。 |
| 别名 | N-甲酰基-L-亮氨酸（1S）-1 - [[（2S，3S）-3-己基-4-氧代-2-氧杂环丁烷基]甲基]十二烷基酯, Ro-18-0647, （-）-四氢脂抑素;N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-Hexyl-4-oxo-2-oxetanyl]methyl]dodecyl Ester; HY-B0218; Tetrahydrolipstatin; Ro-18-0647；(-)-Tetrahydrolipstatin |
