熔点 | 195-205°C |
应用 | 对某些真菌、细菌和病毒有抑制作用,但对神经、心脏等有毒害,可引起麻痹、心脏抑制,甚至导致死亡。 |
生化机理 |
Chelerythrine is potent, cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Chelerythrine has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL to Bak (IC50 = 1.5 μM) or Bad proteins and stimulates apoptosis. |
别名 | 白屈菜赤碱;白屈菜季铵碱;1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride |