熔点 | 270°C |
敏感性 | 对湿度敏感&对光敏感 |
溶解性 | Soluble in DMSO (25 mg/ml), water (0.25 g/100ml) at 25 °C, ethanol (<1 mg/ml) at 25 °C, and DMF (16 mg/ml) |
存贮条件 | 充氩保存 |
密度 | 3.7000 |
应用 |
cis-Diamineplatinum(II) dichloride can be used as a model drug to test the efficiency of various drug carriers in drug delivery. cis-Diammineplatinum(II) dichloride has been used: · in cell viability measurement in cochlear explants · in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines · in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma |
产品介绍 | 微溶于水,易溶于二甲基甲酰胺。在水溶液中可逐渐转化成反式和水解。 |
生化机理 | Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca2+/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks. Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links. |
别名 | 顺双氯双氨络铂,氯氨铂,顺二氯二氨基铂;顺式-二胺二氯铂;顺-二胺二氯铂(II);顺氯氨铂;cis-Dichlorodiammine platinum(II); cis-Platinum(II) diammine dichloride; cis-Diammineplatinum(II) dichloride ; Cisplatin |