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CAS No. : 2056262-07-6
MCE 国际站:BRD3731
产品活性:BRD3731 是一种选择性的 GSK3β 抑制剂,抑制 GSK3β 和 GSK3α 的 IC50 值分别为 15 nM 和 215 nM。BRD3731 有潜力用于创伤后应激障碍 (PTSD) 精神障碍、糖尿病和神经退行性障碍的研究。
研究领域:PI3K/Akt/mTOR | Stem Cell/Wnt
作用靶点:GSK-3
In Vitro: BRD3731 is a GSK3β- selective inhibitor extracted from patent US20160375006A1, compound example 272.
BRD3731 (1-10 μM; 24 hours) inhibits the phosphorylation of CRMP2 in SH-SY5Y cells.
BRD3731 (20 μM; 24 hours) decreases β-catenin S33/37/T41 phosphorylation and induces β-catenin S675 phosphorylation in HL-60 cells.
BRD3731 (10-20 μM; 7-10 days) impairs colony formation in TF-1 and increases colony forming ability in the MV4-11 cell line
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