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SB 415286

CAS No. : 264218-23-7

MCE 国际站：SB 415286

产品活性：SB 415286 是一种有效的 GSK-3α 抑制剂，IC₅₀ 值为 77.5 nM，K_i 值为 30.75 nM；SB 415286 对人 GSK-3α 和 GSK-3β 的抑制效果相同。

研究领域：PI3K/Akt/mTOR  |  Stem Cell/Wnt  |  Apoptosis

作用靶点：GSK-3  |  Apoptosis

In Vitro: SB 415286 (SB-415286) inhibits human GSK-3α with an IC₅₀ of 77.5 nM, and a K_i of 30.75 nM. SB-415286 stimulates glycogen synthesis in the Chang human liver cell line with EC₅₀ of 2.9 μM. SB-415286 stimulates glycogen synthase activity in Chang human liver cells. SB-415286 induces transcription of a β-catenin-LEF/TCF regulated reporter gene in HEK293 cells. SB 415286 (SB-415286, 5-44 μM) attenuates B65 cell loss mediated by 1 mM H₂O₂. SB-415286 (5-44 μM) causes a significant dose-dependent decrease in the fluorescence intensity of DCF, and attenuates B65 ROS production as mediated by 1 mM H₂O₂. SB-415286 (5-44 μM) also attenuates ROS production in CGN mediated by 1 mM H₂O₂. SB-415286 (50 µM) induces a substantial suppression of immunoprecipitated GSK3 activity by 97%.

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