MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 1166827-44-6
MCE 国际站:AZD7687
产品活性:AZD7687 是一种有效的,选择性的,可逆的和具有口服活性的二酰基甘油酰基转移酶 1 (DGAT1) 抑制剂,对人 DGAT1 的 IC50 为 80 nM。AZD7687 可用于 2 型糖尿病和肥胖症研究。
研究领域:Metabolic Enzyme/Protease
作用靶点:Acyltransferase
In Vitro: In an in vitro recombinant mouse, dog, and human DGAT1 enzyme assay, AZD7687 has an IC50 of approximately 100 nM, 60 nM, and 80 nM, respectively. AZD7687 (compound 30) shows inhibition of acyl-CoA:cholesterol acetyltransferase (79% at 10 μM), fatty acid amide hydrolase (IC50 = 3.7 μM), muscarinic M2 receptor (IC50 = 80.5 μM), and phosphodiesterase PDE10A1 (IC50 = 5.5 μM). No activity against human DGAT2 is detected.
In Vivo: Prolonged pharmacological inhibition of DGAT1 with AZD7687 in mice results in the same skin phenotype, including sebaceous gland atrophy and alopecia, as seen in the skin of DGAT1-/- mice. AZD7687-mediated effects on the skin were dose- and time-dependent and reversible.
相关产品:Clinical Compound Library Plus | Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Clinical Compound Library | Anti-diabetic Compound Library | Orally Active Compound Library | Anti-Obesity Compound Library | Lipid Metabolism Compound Library | Highly Selective Inhibitors Library | RP-64477 | PF-06424439 methanesulfonate | E-5324 | RP 73163 Racemate | ACAT-IN-10 | ABT-046 | PF-04620110 | AZD3988 | ACAT-IN-5 | DL-Glyceraldehyde 3-phosphate | Pyripyropene A | K-604 dihydrochloride | Diacylglycerol acyltransferase inhibitor-1 | ACAT-IN-4 | VULM 1457 | Ilexoside XLVIII | DGAT-1 inhibitor 2 | Lecimibide | 2-Furoic acid-d3 | Enniatin A | Glabrol | Avasimibe | FCE 28654 | YM17E | RP 70676 | 2-Furoic acid | GOAT-IN-1 | TP-020
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。