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CAS No. : 26921-17-5
MCE 国际站:(S)-Timolol Maleate
产品活性:(S)-Timolol Maleate (L-714,465 Maleate) 是一种非心脏选择性的亲水性 β-肾上腺素受体 (β-adrenoceptor) 阻滞剂。(S)-Timolol Maleate 通过防止房水的产生而被广泛用作眼压(青光眼)的标准活性分子。(S)-Timolol Maleate 可用于高血压,心绞痛和心肌梗塞的研究。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:Adrenergic Receptor
In Vitro: Timolol maleate represents a chiral compound with one asymmetric carbon in its structure. Single isomer, (S)-enantiomer, is a non-cardioselective β-adrenergic blocker. Its commonest application is in topical treatment of increasing intraocular pressure in patients with chronic open angle glaucoma and also in aphakic patients.
In Vivo: There are reports that indicate lower biological activity of (R)-isomer compared to (S)-isomer. Namely, (R)-timolol is 49 times less potent than (S)-timolol on β-adrenoceptor in animals, 13 times less potent in constricting the airways of normal subjects.
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