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Guanabenz hydrochloride

CAS No. : 23113-43-1

MCE 国际站：Guanabenz hydrochloride

产品活性：Guanabenz hydrochloride 是一种 α-2 肾上腺素受体激动剂，具有口服活性。Guanabenz hydrochloride 具有抗高血压和抗寄生虫活性。Guanabenz hydrochloride 干扰内质网应激信号传导，对心肌细胞具有保护作用。Guanabenz hydrochloride 也被用于高血压的研究。

研究领域：Anti-infection  |  Neuronal Signaling  |  GPCR/G Protein

作用靶点：Parasite  |  Adrenergic Receptor

In Vitro: Guanabenz hydrochloride (0.5-50 μM, 24 h) is treated with increasing concentrations for 24 hours not affect cell viability.
Guanabenz hydrochloride (0.5-50 μM, 24 h) alone not affects the UPR targets, neither on mRNA or protein level nor the phosphorylation status of eIF2a. Guanabenz also not induces GADD34 or the constitutively active form CReP.
Guanabenz hydrochloride (0.5-50 μM, 24 h) alone not induces ER stress in neonatal rat cardiomyocytes.

In Vivo: Guanabenz hydrochloride (5 mg/kg/day; i.p.; for 3 weeks) can reproducibly reduce brain cyst burden.
Guanabenz hydrochloride (5 mg /kg/d, i.p., oral; 10 mg/kg/d, gavage; for 3 weeks) reverses Toxoplasma-induced hyperactivity in latently infected mice.
Guanabenz hydrochloride (100 and 320 μg/kg and 1 mg/kg, i.v., over a period of 5 min at intervals of 40 min) reduces sympathetic outflow, heart rate and blood pressure in debuffered cats.

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