MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
MCE 国际站:Lipopolysaccharides
产品活性:Lipopolysaccharides (LPS) 脂多糖是从革兰氏阴性菌外膜的外叶中提取的内毒素,由一个抗原 O- 特异性链、一个核心寡糖和脂质 A 构成。Lipopolysaccharides 是一种激活免疫系统的致病相关分子模式 (PAMP)。Lipopolysaccharides 激活免疫细胞的 TLR-4。 本产品来源于大肠杆菌 O55:B5。Lipopolysaccharides 诱导细胞迁移体的分泌。
In Vitro: Lipopolysaccharides (10–80 μg/mL) selectively decreases THir (tyrosine hydroxylase immunoreactive) cells and increases culture media levels of interleukin1β (IL-1β) and tumor necrosis factor-α (TNF-α) as well as nitrite (an index of nitric oxide (NO) production).
In Vivo: Lipopolysaccharides can be used in animal modeling to construct a mouse liver inflammation model.
Lipopolysaccharides (1.5 mg/kg; i.p.; once) induces sickness and hypothermia in mice, and induces a greater and more prolonged sickness response in adult male mice.
相关产品:Natural Product Library Plus | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Natural Product Library | Clinical Compound Library | Small Molecule Immuno-Oncology Compound Library | Drug Repurposing Compound Library | Antioxidant Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Antibacterial Compound Library | Pyroptosis Compound Library | Microbial Metabolite Library | Animal Disease Model Inducer Library | Non-steroidal Anti-Inflammatory Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | C29 | ODN 1018 | TLR7 agonist 5 | AN-3485 | ODN 2088 | TLR4/NF-κB/MAPK-IN-1 | TLR9-IN-1 | Complete Freund's adjuvant (CFA) | ODN 105871 | MC-Val-Cit-PAB-Amide-TLR7 agonist 4 | Monophosphoryl lipid A | β-D-Glucan | Poly (I:C):Kanamycin (1:1) (sodium) | ODN TTAGGG | Bropirimine | Polygalasaponin F | Chloroquine-d5 diphosphate | DB-3-291 | ODN 24888 | ODN 2216 | Agatolimod | Enpatoran hydrochloride | BBIQ | UC-1V150 | AZD8848 | ODN 105870 | CU-T12-9 | TLR7/8 agonist 7 | ODN 21158 | TH1020
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。