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CAS No. : 13860-38-3
MCE 国际站：N1-Methylpseudouridine
产品活性：N1-methyl-pseudouridine (1-Methylpseudouridine) 是一种甲基假尿苷，翻译性能优于 5 mC 和 5 mC/N1-methyl-pseudouridine。通过增加核糖体密度，mRNA 中的 N1-methyl-pseudouridine 以 eIF2α 依赖性和独立机制增强翻译。
作用靶点：Nucleoside Antimetabolite/Analog | DNA/RNA Synthesis
In Vitro: Incorporation of N1-methyl-pseudouridine into mRNA modifies mRNAs produced higher amounts of luc than the standard Luc mRNA in HEK293T cells. Incorporation of N1-methyl-pseudouridine nucleoside modification in both Luc and GFP mRNA enhances the initiation step of translation, in part by suppressing eIF2α phosphorylation. In addition, polysome formation and growth on the NN1-methyl-pseudouridine-containing Luc mRNA is enhanced due to the reduction of elongation rate. In all the in vitro translation systems, incorporation of N1-methyl-pseudouridine in Luc and GFP mRNAs dramatically enhanced translation. The N1-methyl-pseudouridine-Luc mRNA is associated with heavier polysomes than Luc mRNA.
In Vivo: N1-methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice.
N1-methyl-pseudouridine (1-Methylpseudouridine) (20 μg; I.m. or i.d. routes for 21 days) and m5C/ N1-methyl-pseudouridine-modified mRNA respectively have a higher translational capacity than Ψ and m5C/Ψ-modified mRNA in vivo.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Reprogramming Compound Library | Glycoside Compound Library | Nucleotide Compound Library | Endoplasmic Reticulum Stress Compound Library | Anti-Lung Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Heterocyclic Compound Library | 2’-dG (iBu)-2’-phosphoramidite | Peldesine dihydrochloride | 3’-Beta-C-Methyl-N6-(m-trifluoromethylbenzyl)adenosine | IBU-DC Phosphoramidite | 8-Methylguanosine | 2,4-D sodium salt | 2'-Deoxy-8-methylamino-adenosine | Thailanstatin D | N6-Isopentenyl-2’-deoxy adenosine, 2’-deoxy riboprine | 7-Ethyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine | Carboplatin-d4 | Caracemide | Farudodstat | 5’-Deoxy-5’-N-methylaminothymidine | N-Acetyl-2′-deoxycytidine | 5-Carboxymethylaminomethyluridine | 3-Deoxy-1,2-O-isopropylidene-5-p-toluoyl-a-D-glycero-pent-3-enofuranose | 3,5-Di-O-benzoyl-2-deoxy-2-fluoro-5-trifluoromethyl-arabinouridine | 6-Mercaptopurine-13C2,15N | 4′,5′-Didehydro-5′-deoxyadenosine | Ara-ATP | 2’,3’,5’-Tri-O-acetyl-5,N3-dimethyluridine | 2’-Deoxy-2’-fluoro-N1-methyluridine | 5'-Homocytidine | 2'-Deoxypseudoisocytidine | 3’-O-DMT-N2-isobutyryl-2’-O-(2-methoxyethyl)guanosine | DNA31 | 5’-Deoxy-5’-iodo-2’-O-(2-methoxyethyl)-5-methyluridine | 2'-OMe-Ac-C Phosphoramidite | 3’,5’-Di-O-benzoyl-2’-deoxy-2’-fluoro-5-methyl-β-D-arabino-uridine
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-112582
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