MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Deucrictibant

CAS No. : 2340111-58-0

MCE 国际站：Deucrictibant

产品活性：Deucrictibant 是一种有效的缓激肽受体 (bradykinin receptor) 拮抗剂。缓激肽受体是细胞表面 G 蛋白偶联受体，属于 7 个跨膜结构域家族。Deucrictibant 是一种从头设计的氘代物。

研究领域：Others  |  GPCR/G Protein

作用靶点：Isotope-Labeled Compounds  |  Bradykinin Receptor

In Vitro: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Potential advantages of deuterated compounds:
(1) Extend the half-life in vivo. Deuterated compounds may be able to prolong the pharmacokinetic characteristics of the compound, that is, prolong the half-life in vivo. This can improve compound safety, efficacy and tolerability, and increase ease of administration.
(2) Improve oral bioavailability. Deuterated compounds may reduce the degree of unwanted metabolism (first-pass metabolism) in the gut wall and liver, allowing a greater proportion of the unmetabolized drug to reach its target site of action. High bioavailability determines its activity at low doses and better tolerance.
(3) Improve metabolic characteristics. Deuterated compounds may reduce the formation of toxic or reactive metabolites and improve drug metabolism.
(4) Improve drug safety. Deuterated compounds may reduce or eliminate adverse side effects of pharmaceutical compounds and are safe.
(5) Preserve the therapeutic properties. Deuterated compounds are expected to retain similar biochemical potency and selectivity to hydrogen analogs in previous studies.

相关产品：(1R,2S,7R)-Sitafloxacin-d₄ hydrochloride  |  Perphenazine-d₈ dihydrochloride  |  Ammonium-¹⁵N,d₄ chloride  |  Lobradimil  |  Enalaprilat-d₅ maleate  |  Doxorubicin-¹³C,d₃ TFA  |  Fmoc-Ser(tBu)-OH-¹³C₃,¹⁵N  |  Prostaglandin F1β-d₉  |  D-Galactose-¹³C-1  |  Diphenyl ether-d₁₀  |  Methyl octanoate-d₁₅  |  Vedaprofen-d₃  |  2-tert-Butylamino-d₉-4-chloro-6-cyclopropylamino-1,3,5-triazine  |  17β-Dihydroequilin 3-sulfate-2,4,16,16-d₄ sodium  |  Pelubiprofen-¹³C,d₃  |  Chlormadinone-d₆  |  2-tert-Butyl-4-hydroxyanisole-d₃  |  6-(5-Chloropyridin-2-yl)-7-oxo-6,7-dihydro-5H-pyrrolo[3,4-b]pyrazin-5-yl piperazine-1-carboxylate-d₈ hydrochloride  |  HT-2 Toxin-¹³C₂₂  |  2,3-Dichloro-1-propanol-d₅  |  (Chlorocarbonyl)cyclohexane-d₁₁  |  Trifloxystrobin-d₃  |  5-Hydroxy tryptophol β-D-glucuronide-d₄  |  3-Sulfo-glycodeoxycholic acid-d₄ disodium  |  Fipronil sulfone-¹³C₆  |  Adenosine-5′-monophosphate-¹⁵N₅ sodium  |  2-Methylpiperazine-d₆  |  Mequinol-d₄  |  tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate-d₄  |  Trifluralin-d₁₄

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-145562

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。