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MCE 国际站：Activin RIB/ALK-4 Protein, Rhesus Macaque (HEK293, Fc)
Activin RIB，也称为激活素受体 1B 型(ACVR1B) 或 ALK-4，是一种 I 型跨膜丝氨酸/苏氨酸激酶受体，是TGF-β 受体超家族的一部分。激活素与 II 型激活素受体 (ACVR2 或 ACVR2B) 结合，然后募集 ACVR1B。Activin RIB/ALK-4 Protein, Rhesus Macaque (HEK293, Fc) 在 HEK293 细胞中表达产生，由 126 个氨基酸(M1-E126) 组成，在 C 末端带有 Fc 标签。
Synonyms: Activin Receptor IB; ALK-4; Activin RIB; ACVR1B
Species: Rhesus Macaque
Source: HEK293
Biological Activity: The enzyme activity of this recombinant protein is testing in progress, we cannot offer a guarantee yet.
研究背景：ALK4, also termed activin A receptor type 1b (ACVR1B), is a transmembrane serine/threonine kinase activin type-I receptor and is highly expressed in the mammal heart. ALK4 is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination.
The sequence of amino acids in ALK4 (ACVR1B) proteins from different species is very stable, which leads to the conclusion that in the process of evolution, ALK4 has been only slightly altered, and that both in humans and in animals, its function is similar.
Activin binds to a type II activin receptor (Acvr2 or Acvr2b) and then recruits ACVR1B. ALK4 (ACVR1B) forms an activin receptor complex with activin type-II receptor to transduce activin signal from the cell surface to the cytoplasm, thus regulating physiological and pathological processes including embryogenesis, tissue homeostasis, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. Receptor heterodimerization activates the type II receptor kinase to phosphorylate the type I receptor, which recruits and phosphorylates regulated Smads2 and 3. Phosphorylated regulated Smads are released and form a heteromeric complex with the Co-Smad, Smad4. The regulated Smad and Co-Smad complex then translocates to the nucleus where it regulates the expression of many genes. In mammals, Acvr1b is expressed by various types of epithelial cells, including interfollicular epidermis, and the outer root sheath (ORS) and the inner root sheath (IRS) of the hair follicles. Activin signaling through Acvr1b acts on skin epithelial cells in a paracrine manner.
ALK4 (ACVR1B), is an important regulator of vertebrate development, with roles in mesoderm induction, primitive streak formation, gastrulation, dorsoanterior patterning, and left-right axis determination. ALK4 also regulates physiological and pathological processes including embryogenesis, tissue homeostasis, wound healing, extracellular matrix production, immunosuppression, and carcinogenesis. ALK4 functions as a tumor-suppressor gene in pancreatic tumorigenesis.
蛋白编号：NP_001252559 (M1-E126)
基因 ID：696587
产品分类：细胞因子和生长因子 | 转化生长因子-β 超家族 | Activin/Inhibins Receptor | 激活素受体 IB | 受体蛋白 | 受体丝氨酸/苏氨酸激酶 | 激活素受体 IB | 酶和调节子 | 丝氨酸/苏氨酸蛋白激酶 | 激活素受体 IB
Categories：Cytokines and Growth Factors | TGF-beta Superfamily | Activin/Inhibins Receptor | ALK-4/Activin RIB | Receptor Proteins | Receptor Serine/Threonine Kinases | ALK-4/Activin RIB | Enzymes & Regulators | Serine/Threonine Kinase Proteins | ALK-4/Activin RIB
货号: HY-P77294
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