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MCE 国际站:PD-L2 Protein, Human (HEK293, Fc)
PD-L2 Protein, Human (HEK293, Fc)是 PD-1 的另一个配体,和PD-1相互作用,负调控T细胞增殖,细胞因子的产生和细胞毒性。
Synonyms: rHuPD-L2, Fc Chimera; Programmed cell death 1 ligand 2; B7DC; CD273
Species: Human
Source: HEK293
Biological Activity: 5 µg/mL (100 µL/well) of immoblized recombinant human PD-L2-Fc can bind human Biotin-PD-1-Fc with a linear range of 2.44-39.06 ng/mL.
研究背景:Programmed death I (PD-I)-deficient mice develop a variety of autoimmune-like diseases, which suggests that this immunoinhibitory receptor plays an important role in tolerance. PD-1 ligand 2 (PD-L2) is a second ligand for PD-1. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4+ T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals. In contrast, at high antigen concentrations, PD-L2-PD-1 interactions reduce cytokine production but do not inhibit T cell proliferation. PD-L-PD-1 interactions lead to cell cycle arrest in G0/G1 but do not increase cell death. In addition, ligation of PD-1 + TCR leads to rapid phosphorylation of SHP-2, as compared to TCR ligation alone.
蛋白编号:Q9BQ51 (L20-P219)
基因 ID:80380
产品分类:免疫检查点蛋白 | 抑制性免疫检查点 | B7-DC/PD-L2 | CD 抗原 | 巨噬细胞 CD 蛋白 | B7-DC/CD273 | CD 抗原 | 单核细胞 CD 蛋白 | B7-DC/CD273 | CD 抗原 | 树突细胞 CD 蛋白 | B7-DC/CD273
Categories:Immune Checkpoint Proteins | Inhibitory Checkpoint Molecules | B7-DC/PD-L2 | CD Antigens | Macrophage CD Proteins | B7-DC/CD273 | CD Antigens | Monocyte CD Proteins | B7-DC/CD273 | CD Antigens | Dendritic Cell CD Proteins | B7-DC/CD273
货号: HY-P7399
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