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IL-22R alpha 1 Protein, Human (HEK293, Fc)

MCE 国际站：IL-22R alpha 1 Protein, Human (HEK293, Fc)

IL-22R alpha 1 (IL22RA1) Protein 是一种 IL-22 受体。IL-22R alpha 1 Protein 与 IL22 相互作用激活 JAK/STAT 级联，从而抑制 IL-22 介导的细胞增殖和抗凋亡。 IL-22R alpha 1 Protein, Human (HEK293, Fc) 是由 HEK 293 细胞表达的，具有跨膜区 (H16-T228)，C 端带有 Fc 标签。

Synonyms: IL-22R-alpha-1; IL-22RA1; CRF2-9; IL22R; IL22R1; IL-TIF-R1; zcytoR11

Species: Human

Source: HEK293

Biological Activity: 1.Immobilized Human IL-22, His Tag at 2 μg/ml (100 μl/Well) on the plate. Dose response curve for Human IL-22R alpha 1, hFc Tag with the EC₅₀ of 10.2 ng/ml determined by ELISA.
2.Immobilized Human IL-22R alpha 1, hFc Tag at 0.5 μg/mL (100 μl/well) on the plate. Dose response curve for Biotinylated Anti-IL-22R alpha 1 Antibody, hFc Tag with the EC₅₀ of 11.2-18.4 ng/ml determined by ELISA.

研究背景：IL-22R alpha 1 (IL22RA1) Protein is a single-pass type I membrane protein. IL-22R alpha 1 expresses in colon, liver, lung, pancreas and kidney. IL-22R alpha 1 is primarily present on epithelial cells and certain monocyte subsets, and very limited IL-22R alpha 1 expression is found on other immune cells.
The sequence of amino acids in IL-22R alpha 1 from different species is very different (less than 85% similarity among human, rat and Canine).
IL-22R alpha 1 is an essential component of the high-affinity IL-22 receptor enabling IL-22 signaling via JAK/STAT pathways. IL-22R alpha 1 is a component of one of the receptors for IL-20 and IL-24 formed and signaling through STATs activation. IL-22R alpha 1 mediates IL-24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation.

蛋白编号：Q8N6P7 (H16-T228)

基因 ID：58985

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-22 受体  |  白介素-22 受体 α1

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-22 Receptor  |  IL-22R alpha 1

货号: HY-P77967

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