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CAS No. : 839707-37-8
MCE 国际站:Pluripotin
产品活性:Pluripotin 是 ERK1 和 RasGAP 的双重抑制剂,KD 分别为 98 nM 和 212 nM。Pluripotin 还抑制 RSK1,RSK2,RSK3 和 RSK4,IC50 分别为 0.5,2.5,3.3 和 10.0 μM。
研究领域:MAPK/ERK Pathway | Stem Cell/Wnt
作用靶点:Ribosomal S6 Kinase (RSK) | ERK
In Vitro: Pluripotin (SC-1) inhibits Abl1, p70S6K, PLK2, RSK1, RSK2, RSK3, RSK4 with IC50s of 0.005, 1.4, 2.2, 0.5, 2.5, 3.3, 10.0 µM,respectively. Pluripotin (SC-1) decreases cell growth for 7 colon tumor cell lines. After a five day exposure to 0.1 µM SC-1, the seven colon tumor lines are evaluated for changes in cell number and viability. There is a statistically significant decrease in cell number but >95% viability.
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货号: HY-10579
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