MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

CTPI-2

CAS No. : 68003-38-3

MCE 国际站：CTPI-2

产品活性：CTPI-2 是第三代特异性线粒体柠檬酸盐载体 SLC25A1 抑制剂，K_D 为 3.5 μM。CTPI-2 抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。CTPI-2 阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。具有抗肿瘤活性。

研究领域：Metabolic Enzyme/Protease

作用靶点：Mitochondrial Metabolism

In Vivo: CTPI-2 is a unique regulator of glycolysis that limits the metabolic plasticity of cancer stem cells (CSCs). CTPI-2 (26 mg/kg; i.p.) inhibits tumor growth in in vivo models of non-small cell lung cancer (NSCLC).
CTPI-2 (50 mg/kg; i.p.; alternate days for 12 weeks) completely averts weight gain in the prevention study and leads to significant weight loss in the reversion study.
CTPI-2 prevents steatohepatitis and normalizes glucose tolerance. CTPI-2 lowers the levels of circulating IL-6 while increasing anti-inflammatory IL-4 and IL-10 and also reduced the monocyte chemoattractant protein-1 and monokine-induced by interferon-γ that attract neutrophils and monocytes. CTPI-2 regulates the citrate pool, the lipogenic and the gluconeogenic pathways.

相关产品：Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Metabolism/Protease Compound Library  |  Stem Cell Signaling Compound Library  |  Anti-Cancer Compound Library  |  Anti-Aging Compound Library  |  Reprogramming Compound Library  |  Glycolysis Compound Library  |  Glutamine Metabolism Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Parkinson's Disease Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Mitochondria-Targeted Compound Library  |  Glucose Metabolism Compound Library  |  Cuproptosis Compound Library  |  Cancer Stem Cells Compound Library  |  Mitochondrial Protection Compound Library  |  Ciprofloxacin  |  VLX600  |  Fumarate hydratase-IN-2 sodium salt  |  Thiabendazole  |  Daidzin  |  Tubulin/HDAC-IN-1  |  Kresoxim-methyl  |  T0467  |  Idebenone  |  D-Histidine  |  Azoramide  |  Glutamate dehydrogenase (NAD(P))  |  Complex III-IN-1  |  Mitochonic acid 5  |  Ferulenol  |  Myxothiazol  |  MitoTam iodide, hydriodide  |  α-Lipoic Acid-d₅  |  HP661  |  Genistein 8-c-glucoside  |  Mito-LND  |  KL1333  |  MSDC 0160  |  UK-5099  |  Afzelin  |  Tempo-d₁₈  |  Mitochondrial respiration-IN-1 hydrobromide  |  CCCP  |  THP104c

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

货号: HY-123986

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。