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Stavudine

CAS No. : 3056-17-5

MCE 国际站：Stavudine

产品活性：Stavudine (d4T) 是一种口服活性核苷逆转录酶抑制剂 ((NRTI))。Stavudine 具有抗 HIV-1 和 HIV-2 的活性。Stavudine 还抑制线粒体 DNA (mtDNA) 的复制。Stavudine 降低 NLRP3 炎症小体激活，调节淀粉样 β 自噬。Stavudine 诱导细胞凋亡。

研究领域：Anti-infection  |  Cell Cycle/DNA Damage  |  Immunology/Inflammation  |  Autophagy  |  Apoptosis

作用靶点：Reverse Transcriptase  |  HIV  |  Nucleoside Antimetabolite/Analog  |  NOD-like Receptor (NLR)  |  Autophagy  |  Apoptosis

In Vitro: Stavudine (d4T) (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages.
Stavudine (d4T) (50 μM) inhibits the assembly of the NLRP3 inflammasome complex and down-regulates the phagocytosis of Aβ 42 by macrophages.
Stavudine (d4T) (10 μM, 7 or 14 days) significantly induced CEM cells apoptosis, especially after 14 days, and increases hydrogen peroxide levels.

In Vivo: Stavudine (d4T) (500 mg/kg, daily liquid, 2 weeks) can rapidly induce fat depletion and mild liver damage at high dose in male RjOrl Swiss mice.

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