GSTA1 蛋白, Human (HEK293, C-His) | MedChemExpress (MCE)
Synaptotagmin VI 蛋白, Human (N-His) | MedChemExpress (MCE)
Galectin-8 蛋白, Rat (His) | MedChemExpress (MCE)
S100A14 蛋白, Human (His, solution) | MedChemExpress (MCE)
S100A13 蛋白, Mouse (N-His) | MedChemExpress (MCE)
Fc gamma RIIIA/CD16a 蛋白, Rat (HEK293, C-His) | MedChemExpress (MCE)
MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 141064-23-5
MCE 国际站:Xanomeline oxalate
产品活性:Xanomeline oxalate (LY246708 oxalate) 是一种有效的、选择性毒蕈碱受体激动剂 (SMRA),可刺激体内的磷酸肌醇水解。 Xanomeline oxalate 可用于研究阿尔茨海默氏病。
研究领域:GPCR/G Protein | Neuronal Signaling
作用靶点:mAChR
In Vitro: Xanomeline stimulates phosphoinositide (PI) hydrolysis in the A9 L m1 cells.
Xanomeline inhibits [3H]-pirenzepine ([3H]-PZ) and [3H]-oxotremorine-M ([3H]-OXO-M) binding to rat brain with Kis of 7 and 3 nM, respectively.
In Vivo: Xanomeline robustly stimulates in vivo PI hydrolysis and the effect is blocked by muscarinic antagonists, demonstrating mediation by muscarinic receptors. In mice the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 54 μmole/kg in hippocampus. And in rats the ED100 for Xanomeline-induced stimulation of [3H]-IP accumulation is 8.1 μmole/kg in hippocampus.
相关产品:Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | Anti-Alzheimer's Disease Compound Library | Neurodegenerative Disease-related Compound Library | Human Metabolite Library | Anti-Pulmonary Fibrosis Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Highly Selective Activators Library | VU0357017 hydrochloride | 5-Hydroxy tryptophol β-D-glucuronide-d4 | TBPB | Tropicamide-d3 | Imidafenacin | (±)-Muscarine chloride | mAChR-IN-1 hydrochloride | Scopolamine butylbromide | Navafenterol | Fustin | Penehyclidine | VU 0255035 | DREADD agonist 21 | Umeclidinium-d5 bromide | Cevimeline | Methacholine bromide | Iperoxo | VU0467485 | M4 mAChR agonist-1 | Clozapine | Brompheniramine maleate | Umeclidinium bromide | Zamifenacin fumarate | Parapenzolate bromide | (-)-Cevimeline hydrochloride hemihydrate | LY2119620 | Milameline hydrochloride | β2AR/M-receptor agonist-2
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-13410
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。