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CAS No. : 2049973-02-4
MCE 国际站:AM-8123
产品活性:AM-8123 是一种口服有效的 APJ 激动剂。AM-8123 抑制 Forskolin 诱导的 cAMP 的生成,促进 Gα 蛋白活化。AM-8123 可用于心血管疾病的研究。
研究领域:GPCR/G Protein
In Vitro: AM-8123 (100 nM) causes a rapid β-arrestin translocation from cytoplasm to plasma membrane in APJ-expressing cells. AM-8123 bound the native hAPJ receptor with low nanomolar affinity.
In Vivo: AM-8123 (100 mg/kg; p.o.) results in sustained improvement in systolic function and decreases both EDV and ESV as measured by echocardiography but not by the invasive pressure-volume conductance catheter at study termination.
AM-8123 (0.035, 0.09, 0.9, and 9 mg/kg; i.v.) improves cardiovascular function.
AM-8123 exhibits appreciably greater oral bioavailability in rats and dogs relative to pyr-apelin-13. AM-8123 infusion results in an increase in EF, SV, and dP/dt max at submicromolar unbound plasma concentrations with minimal change in HR, indicating that acute infusion of AM-8123 is associated with an improvement in several markers of cardiac function. AM-8123 is a more potent mediator of both ERK and AKT phosphorylation relative to pyr-apelin-13.
相关产品:APJ receptor agonist 1 | CMF019 | Apelin-13 TFA | APJ receptor agonist 4 | [Pyr1]-Apelin-13 | ELA-21 (human) | ELA-11(human) TFA | APJ receptor agonist 6 | ELA-32(human) TFA | NH2-c[X-R-L-S-X]-K-G-P-(D-2Nal) | ML233 | Elabela(19-32) | APJ receptor agonist 5 | NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) | ML221 | Azelaprag | (Ala13)-Apelin-13 | MM 07 | Apelin agonist 1 | MM 54 | APJ receptor agonist 3
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