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CAS No. : 1496508-34-9
MCE 国际站:Dazucorilant
产品活性:Dazucorilant (CORT113176) 是一种非甾体糖皮质激素受体 (GR) 调节剂,在体外其 Ki 值 <1 nM。Dazucorilant 可用于神经系统疾病的研究。
研究领域:Immunology/Inflammation | Vitamin D Related/Nuclear Receptor
In Vitro: In HepG2 human cells or in human hepatocytes, Dazucorilant acts as full antagonist since it is able to prevent the dexamethasone-induced increase in TAT activity and to induce non-measurable agonist activity in the absence of dexamethasone.
In Vivo: Dazucorilant (30 mg/kg/day; s.c.) makes mice show reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity.
Dazucorilant (5, 10 or 20 mg/kg; i.p.) reverses hippocampal amyloid-β peptide generation, neuroinflammation and apoptotic processes, restores the hippocampal levels of synaptic markers, reestablishes basal plasma levels of glucocorticoids and improves cognitive function at a dose of 10 mg/kg.
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