MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务。
CAS No. : 1026582-88-6
MCE 国际站:RO-3
产品活性:RO-3 是一种有效的,具有口服活性的,能通过大脑的 P2X3 和 P2X2/3 拮抗剂,对人同型多聚体 P2X3 和异型多聚体 P2X2/3 受体的 pIC50 分别为 5.9 和 7.0。RO-3 对 P2X3 和 P2X2/3 的选择性高于所有其他功能性同型多聚体 P2X 受体 (IC50 >10 μM at P2X1,2,4,5,7)。
研究领域:Membrane Transporter/Ion Channel
作用靶点:P2X Receptor
In Vivo: In a guinea pig ureter-afferent nerve preparation, and mouse bladder-pelvic nerve preparation, RO-3 dose-dependently reduces afferent nerve activity induced by distension or α,β-meATP.
RO-3 has activity in several rodent models of pain, as well as in cystometry models optimized to measure various parameters associated with sensory regulation of the micturition reflex.
RO-3 has moderate to high metabolic stability in rat and human hepatocytes and liver microsomes, and is highly permeable, orally bioavailable (14%), and has a reasonable in vivo plasma half-life (t1/2=0.41 h) in rats.
相关产品:Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | CNS-Penetrant Compound Library | Orally Active Compound Library | Neurotransmitter Receptor Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | (E/Z)-Sivopixant | AF-353 | Gefapixant | P2X3 antagonist 34 | Minodronic acid | MRS4738 | AZ 11645373 | Indophagolin | PPNDS tetrasodium | Bullatine A | JNJ-54166060 | P2X7 receptor antagonist-2 | A-317491 | Ro-51 | A-804598 | P2X7-IN-2 TFA | α,β-Methylene-ATP | A 438079 hydrochloride | Taspine | Blue FPG-A trisodium | GSK-1482160 | KN-62 | JNJ-55308942 | Zeaxanthin dipalmitate | H-Lys-Tyr-OH TFA | Lu AF27139 | GW791343 dihydrochloride | NF279 | JNJ-54175446
热门产品线:重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物 | 寡核苷酸 | 抗体 | 点击化学
Trending products:Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides | Antibodies | Click Chemistry
货号: HY-19978
品牌介绍:
• MCE (MedChemExpress) 拥有200 多种全球独家化合物库,我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物;
• 50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领;
• 产品种类涵盖各种重组蛋白,多肽,常用试剂盒 ,更有 PROTAC、ADC 等特色产品,广泛应用于新药研发、生命科学等科研项目;
• 提供虚拟筛选,离子通道筛选,代谢组学分析检测分析,药物筛选等专业技术服务;
• 设有专业的实验中心和严格的质控、验证体系;
• 提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;
• 产品的生物活性多经各国客户实验验证;
• Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;
• 专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;
• 与世界各大制药公司及知名科研机构建立了长期的合作。