MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

IL-2R alpha/CD25 Protein, Human (191a.a, HEK293, His)

MCE 国际站：IL-2R alpha/CD25 Protein, Human (191a.a, HEK293, His)

IL-2R alpha (CD25) 是高亲和力 IL-2 受体的重要组成部分。IL-2R alpha 增强 IL-2 与其受体复合物的结合，从而调节 T 细胞生长和其他淋巴功能。IL-2R alpha/CD25 Protein, Human (191a.a, HEK293, His) 是一种重组人 IL-2R alpha 蛋白，在 HEK293 细胞中表达，由 191 个氨基酸组成 (L23-C213)，C 末端带有 His 标签。

Synonyms: rHuIL-2Rα, His; TAC-antigen; CD25

Species: Human

Source: HEK293

Biological Activity: The ED₅₀ is <1.5 μg/mL as measured by murine CTLL-2 cells.

研究背景：IL-2R alpha (CD25) is a type I membrane protein. IL-2R alpha is expressed in peripheral activated T and B cells, triple-negative thymocytes, and bone marrow pre-B cells. In high tumor regulatory T (Treg) cells, IL-2R alpha is highly expressed and is a potential target for Treg deletion. The expression of IL-2R alpha is undetectable on resting T cells.
The sequence of amino acids in IL-2R alpha from different species is very different (less than 85% similarity among human, rat and mouse).
IL-2R alpha is an essential component of high-affinity IL-2 receptors and has no signal-transducing activity per se. IL-2R alpha functions through enhancing binding of IL-2 to its receptor complex and acts as a positive feedback regulator. IL-2 is a principal growth factor for T lymphocytes and plays an important role in T cell immune response. IL-2R alpha transcription is regulated by three positive regulatory regions (PRRs): PRRI, PRRII and PRRIII. PRRIII is an IL-2 response element.
IL-2R alpha regulates T cell growth, augments lymphocyte activation and proliferation. IL-2R alpha is involved in preventing type 1 diabetes and cancers.

蛋白编号：P01589 (L23-C213)

基因 ID：3559

产品分类：细胞因子和生长因子  |  白细胞介素  |  白介素-2 受体  |  白介素-2 受体 alpha  |  CD 抗原  |  T 细胞 CD 蛋白  |  CD25/IL-2R alpha  |  CD 抗原  |  B 细胞 CD 蛋白  |  CD25/IL-2R alpha  |  CD 抗原  |  NK 细胞 CD 蛋白  |  CD25/IL-2R alpha

Categories：Cytokines and Growth Factors  |  Interleukin & Receptors  |  IL-2 Receptor  |  IL-2R alpha  |  CD Antigens  |  T Cell CD Proteins  |  CD25/IL-2R alpha  |  CD Antigens  |  B Cell CD Proteins  |  CD25/IL-2R alpha  |  CD Antigens  |  NK Cell CD Proteins  |  CD25/IL-2R alpha

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种全球独家化合物库，我们致力于为全球科研客户提供前沿最全的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；
•   专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；
•   与世界各大制药公司及知名科研机构建立了长期的合作。