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Letrozole

CAS No. : 112809-51-5

MCE 国际站：Letrozole

产品活性：Letrozole (CGS 20267) 是一种有效的，选择性的，可逆的和具有口服活性的非甾体类芳香化酶 (aromatase) 抑制剂，IC₅₀ 值为 11.5 nM。Letrozole 选择性抑制雌激素的生物合成，可用于乳腺癌的研究。

研究领域：Metabolic Enzyme/Protease  |  Autophagy

作用靶点：Cytochrome P450  |  Autophagy

In Vitro: Letrozole (0.1-100 nM; 24-96 h) significantly inhibits growth of the MCF-7 epithelial breast cancer cells in a dose- and time-dependent manner.
Letrozole (10 nM) significantly suppresses the stimulatory effects of testosterone on MCF-7 cell proliferation.
Letrozole (10 nM; 24-48 h) suppresses the levels of secreted metalloproteinases (MMP‐2 and MMP‐9) in MCF-7 cells.

In Vivo: Letrozole (3-300 μg/kg; oral gavage once daily for 6 weeks) exhibits anti-tumor effects in rats.

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