Resomelagon acetate 产品活性：Resomelagon (AP1189) acetate 是一种口服有效的黑素皮质素受体 (MR) 激动剂，包括 MC1 and 和MC3。Resomelagon acetate 诱导 ERK1/2 磷酸化和 Ca2+ 流动。Resomelagon acetate 具有抗炎活性。Resomelagon acetate 可用于肥胖和慢性炎症研究。 产品来源： https://www.medchemexpress.cn/resomelagon-acetate.html 研究领域：GPCR/G Protein | Neuronal Signaling 作用靶点：Melanocortin Receptor In Vitro: Resomelagon acetate (0-1000 μM; 8 min; HEK293A cells) promotes melanocortin signal transduction through ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon acetate (1 nM; 30 min; peritoneal macrophages) has anti-inflammatory activity and inhibits TNF-α release and efferocytosis. In Vivo: Resomelagon acetate (0-10 mg/kg; i.p., i.v. and p.o.; for 24 h; male C57BL/6J wild-type (WT) and BALB/c mice) promotes resolution of acute inflammation in vivo. Resomelagon acetate (25-50 mg/kg; p.o.; daily, for 8 d; male C57BL/6J wild-type (WT) and BALB/c mice) reduces arthritis in mice. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Neuronal Signaling Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Orally Active Compound Library | Anti-Obesity Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Bioactive Compound Library Max | α-MSH | Melanotan I | SHU 9119 | BMS-470539 dihydrochloride | Bremelanotide Acetate | Nonapeptide-1 acetate salt | JNJ-10229570 | THIQ | Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA | HS024 TFA | β-Melanocyte Stimulating Hormone (MSH), human TFA | Dersimelagon | MK-0493 | PF-00446687 | SNT-207707 | ACTH (1-17) (TFA) | Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA) | MSG606 | SNT-207858 free base | [D-Trp8]-γ-MSH | Adrenocorticotropic Hormone (ACTH) (4-10), human | Agouti-related Protein (AGRP) (83-132) Amide (human) (TFA) | Fenoprofen | PF-07258669 | ACTH (11-24) | HS014 TFA | ML-00253764 hydrochloride | PG-931 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。