This application shows the advantages of using the Thermo Scientific™ Accucore™ Vanquish™ C18 UHPLC, 1.5 μm column and Vanquish UHPLC system for the analysis of 47 illicit drugs.

　　Advanced capabilities of the Vanquish UHPLC system allow the Accucore Vanquish UHPLC columns to be operated at high flow rates that enable development of rapid analytical methods while maintaining performance. The need for chromatographic separation of isobaric compounds prior to MS detection is also highlighted.