产品描述
1. L-type calcium channel (CaV1.2)
|
Channel |
Cav1.2/β2/α2/δ1, L-type |
|
Catalog Ref. |
ICE-CHO-Cav1.2 |
|
Gene |
CACNA1C |
|
Sources |
human |
|
Expression system |
CHO |
|
Method |
whole cell patch clamp |
|
Reference Inhibitor |
Nifedipine(31.3nM±6.8nM), verapamil |
|
Target |
Timothy syndrome, long QT syndrome, Pain, epilepsy, hypertension, stroke, arrhythmia, Autism |
2、N-type calcium channel (CaV2.2)
|
Channel |
Cav2.2/β3/α2δ1 , N-type |
|
Catalog Ref. |
ICE-CHO-Cav2.2 |
|
Gene |
CACNA1B |
|
Sources |
human |
|
Expression system |
CHO |
|
Method |
whole cell patch clamp |
|
Reference compound |
Nifedipine, verapamil, Cadmium (IC50=7.0µm±704nM) |
|
Target |
Pain, Spinal cord injury, Kleefstra syndrome |
3、T-type calcium channel (CaV3.2)
|
Channel |
CaV3.2, T-type |
|
Catalog Ref. |
ICE-CHO-Cav3.2 |
|
Gene |
CACNA1H |
|
Sources |
human |
|
Expression system |
HEK293 |
|
Method |
whole cell patch clamp |
|
Reference compound |
Nifedipine, verapamil, NiCl |
|
Target |
Convulsion |
4、P/Q-type calcium channel (CaV2.1)
|
Channel |
Cav2.1 |
|
Catalog Ref. |
ICE-CHO-Cav2.1 |
|
Gene |
CACNA1A |
|
Sources |
human |
|
Expression system |
CHO |
|
Method |
whole cell patch clamp |
|
Reference inhibitor |
Cadmium (2.9 ± 0.658µM) |
|
Target |
migraine, seizure and ataxia syndromes |
