Human Prostate Cancer Copy Number PCR Array The Human Prostate Cancer qBiomarker Copy Number PCR Array profiles the copy number of 23 genes reported to undergo frequent genomic alterations in human prostate tumor DNA. Prostate cancer is a heterogeneous group of neoplasms with a broad spectrum of pathologic and molecular characteristics and clinical behaviors. Recent studies have uncovered gene copy number alterations as a major mechanism that contributes to disease progression, including development of resistance to androgen ablation therapy. The genes on the array encode transcription factors, cell surface molecules, channels and transporters, receptors and co-receptors, and intracellular signaling proteins that regulate processes such as the cell cycle, wound healing, prostate development, and platelet activation/blood coagulation. Genes were chosen from the most frequently amplified or deleted genes relevant to oncogenic pathways and prostate cancer biology based on the primary literature and public databases. This array may serve as a useful tool to help classify prostate cancer samples by genotype and help verify prostate cancer phenotypic biomarkers. The array analyzes each gene in each sample in quadruplicate and includes a stable multi-copy reference assay for accurate copy number determination via appropriate DNA input normalization. The simplicity of the product format and operating procedure allow routine and reliable copy number profiling in any research laboratory with access to a real-time PCR instrument.
The qBiomarker Copy Number PCR Arrays are intended for molecular biology applications. This product is not intended for the diagnosis, prevention, or treatment of a disease.
96-well Plate, 384-well (4 × 96) Plate, and 100-well Disc formats are available.    

Cell Cycle: CDKN1B, MCM7.
Cell Surface Receptors: IL11RA, LPAR6.
Channels & Transporters: ABCB1, KCNMA1.
Cytoskeleton Regulation: LCP1, VCL.
Epigenetics: HMGN1.
MAP Kinase Signaling: MAP3K7, RAF1.
Protein Tyrosine Kinases: FGR.
RAS Signaling: NRAS, RAF1.
Transcription Factors: AR, ERG, ETS2, NCOA2, NKX3-1, RUNX1T1.
Ubiquitin Ligase: HACE1, WWP1.
Others: PLAU, PSAP.