文章案例1:研究构建H2AX低表达A549细胞,与对照A549细胞进行表达谱检测,经差异分析和功能通路富集分析后,构建全局信号转导网络,根据属性值degree筛选排名前十的基因,进一步采用PCR验证。(芯片检测+数据分析由中康博提供)
参考文献:Chengrong Lu et al. Genome-wide transcriptional analysis of apoptosis-related genes and pathways regulated by H2AX in lung cancer A549 cells. Apoptosis. 2013 .
文章案例2:实验分为对照组 和SiNPs处理组,斑马鱼为研究对象,对两分组3:3样本进行表达谱检测, 经差异和功能通路富集后,进一步构建全局信号转导网络,筛选出核心的差异基因,并根据degree值及自身研究选择个基因(如jak1、jak2a)进一步验证。(芯片检测+数据分析由中康博提供)
参考文献:Genome-wide transcriptional analysis of cardiovascular-related genes and pathways induced by PM2.5 in human myocardial cells. 2017. Environ Sci Pollut Res.
GSEA Network-gsea network
miRNA-miRNA-correlation Network-mirna-mirna-correlation network
Gene Set Enrichment Analysis(GSEA)-gene set enrichment analysis(gsea)
GOEA Analysis-goea analysis
CircRNA-mRNA-miRNA-Network-circrna-mrna-mirna-network
lncRNA Target Pathway Network-lncrna target pathway network