ArrheniusOne is an innovative state-of-the-art microwave generator and applicator for continuous-flow, microwaveassisted organic synthesis (CF-MAOS) in drug development.
Combining continuous flow with microwave heating can significantly reduce total process times during the development of pharmaceutical compounds. The rapid, uniform heating provided by the ArrheniusOne delivers 10 to 1000 times faster reaction rates within minutes. Continuous flow allows more compound to be produced safely while consuming less energy and producing less waste. Reaction conditions are quickly optimised, thereby eliminating the need for re-optimisation during scale-up and so saving time downstream.
Developed by microwave technology specialist WaveCraft of Sweden and marketed jointly by Uniqsis and WaveCraft, the ArrheniusOne is designed to operate with two- or four-channel FlowSyn continuous flow reactor systems from Uniqsis. The two products combine to offer a unique solution for rapid optimisation and scale-up of compound production to dramatically increase productivity and efficiency, while reducing energy consumption and environmental impact.
Typical CF-MAOS applications include catalysed styrene synthesis, catalysed Suzuki−Miyaura coupling, Fischer indole synthesis, Claisen rearrangement and many others.
ArrheniusOneTM出现是微波合成领域一次新的突破与腾飞，代表着zei新的连续流动微波合成技术(CF-MAOS)广泛应用于制药领域。
结合连续流动与微波加热可大幅度提高合成药物中间体的效率，缩短中间过程和研发时间。通过ArrheniusOneTM可以使反应速度在瞬间提高10~1000倍，加之流动合成具有合成效率高，消耗原料和能耗少，反应平稳安全等特点，这样就可以大大缩短研发时间，为生产放大优化条件。
ArrheniusOneTM由瑞典WaveCraft公司工程师研发，同Uniqsis公司一起担当市场开发。ArrheniusOneTM可配套FlowSynTM 实现2路或4路流动进料，两种方式都配有专属的合成方案来优化选择反应条件和放大，以提高反应效率和产率，并减少资源消耗和对环境的影响。
典型的CF-MAOS反应包括 苯乙烯催化合成、Suzuki−Miyaura催化耦合反应、费舍尔吲哚合成、克莱森重排反应等等
ArrheniusOneTM技术参数
| 微波加热组件 |
| 温度范围 | 室温→300°C |
| 温度增量 | 1→5°C（取决于反应物质、流速、微波功率） |
| 压力范围 | 3mm管道：常压到50Bar;6mm管道：常压到30Bar |
| 微波功率 | 0→150W |
| 微波频率 | 2.4→2.5GHz |
| 反应体积 | 取决于反应情况以及流速控制 |
| 单元功率（zei大） | 600VA |
| 电源要求 |
| 电压 | 110→240V |
| 频率 | 50或60Hz |
| 单元功率（zei大） | 600VA |
| ArrheniusOneTM |
| 工作温度 | 18→32°C |
| 湿度 | 无结露 |
| 冷却液体 | 自来水或循环冷却装置，zei高温度20°C，流速1→5L/min,zei大压力4Bar |
| 重量 | 微波发生器：9.35KG ；工作区域含红外温度探头：6.1KG |
| 尺寸（W*D*H) | 微波发生器：145*320*330mm ；工作区域：180*305*435mm |
| 工作站要求 |
| 笔记本或台式机 | 2 GHz CPU，2G内存，100G硬盘
分辨率：1024*720 ，至少1个USB接口（2.0或1.1），XP/Vista/Windows 7 操作系统（32位或64位） |
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