白血病基因表达PCR芯片

      白血病基因表达PCR芯片可用于研究与白血病的发生、分类和治疗反应有关的84个关键基因的表达。白血病可以根据其发病情况划分为急性或慢性，会影响正常的血液细胞功能和分子生物学通路，包括炎症和免疫反应、JAK-STAT信号通路、淋巴细胞和骨髓细胞的发育和分化。芯片包含这些通路的相关基因，常见的白血病治疗靶基因，以及通过分子生物学分析与高通量芯片筛查检测白血病样本得到的表达差异基因和启动子甲基化的差异基因。利用该芯片研究者即能够利用该芯片简单可靠地同时检测白血病的发生和发展相关的基因表达。

Differentially Methylated Promoters: APAF1, CADM1, CDH1, CDH13, CDKN1A, CDKN1B, CDKN1C, CDKN2B, DAPK1, DKK3, DLC1, EGR3, HIC1, JUNB, MEIS1, MLH1, NPM1, PTEN, SFRP2, SFRP4, SFRP5, SOCS1, TP53, WIF1.

BCR-ABL PAthway: ABL1, BCR, GRB2, JAK2, SHC1, STAT3, STAT5A, STAT5B.

JAK-STAT Signaling: AKT1, CSF3, IFNA1, IL4, IL6, JAK2, STAT1, STAT3, STAT5A, STAT5B, SOCS1. Hemopoiesis: BCL2, CSF3, CTNNB1, IL4, JAK2, LMO2, PML, RUNX1, STAT5A, STAT5B, TAL1, TP53.

Myeloid Cell Differentiation: CTNNB1, FOXO3, IL4, JUN, LMO2, RUNX1, SPI1, STAT5A, STAT5B, TAL1.

Immune System Development: BCL2, CSF3, CTNNB1, IL4, JAK2, LMO2, MLH1, PML, RUNX1, STAT5A, STAT5B, TAL1, TLX1, TP53.

Lymphocyte Prolifeion/Differentiation: BCL2, CSF3, CTNNB1, IL4, IL6, STAT5A, STAT5B.

Cytokines & Chemokines: CCL3, CSF3, CXCL10, IFNA1, IL1R1, IL4, IL6, IL8, IL10, IL12A.

Malignancy: BAALC, BMPR1B, BTG3, CD34, CDC42EP3, CTGF, GAS2L3, MN1, NR4A3, RGS12.

Leukemia Therapeutic Targets: AKT1, ALOX5, BCL2, CTNNB1, FGR, FOXO3, HCK, HDAC1, HSP90AA1, IFNA1, JAK2, MCL1, MERTK, MTOR, PML, PRKCB, RAC2, SMO.

Leukemia Stem Cell Transcriptional Regulators: CEBPB, GATA1, IKZF3, JUN, LMO1, LMO2, LYL1, MEIS1, NFKB1, RUNX1, RUNX2, RUNX3, SPI1, STAT1, STAT3, STAT5A, TAL1, TLX1, TLX3.