动物无创全身体积描记系统/无创型动物肺功能检测仪

WBP清醒无约束动物气道高反应检测系统 (Conscious, Unrestrained, Non-invasive)

?无须麻醉的无创检测方法，动物清醒并可自由活动；  
?操作简单方便，可同时检测数十只动物，适合于大量筛选实验；  
?尤其适用于长期跟踪研究，同只动物多次重复实验；  
?提供呼吸速率、潮气量、呼气峰值、吸气峰值、Penh等参数；  
?提供从啮齿类到非人灵长类动物的各种全身体积描记器。
 

无创型动物肺功能检测系统/全身体积描记器

Whole body plethysmography is an application whereby ventilatory parameters are measured while the subject is conscious and unrestrained. By the use of bias airflow supplies, CO2 levels, temperature and humidity are maintained at normal levels enabling measurements to be made over several hours.
During inspiration there is a slight net pressure rise within theplethysmograph due to increased temperature and humidity of the air as it enters the subject’s lungs (gas conditioning). During normal breathing, this pressure difference is directly proportional to the respiratory pattern of the subject, allowing the researcher to measure respiratory rate and tidal volume, in accordance with ICH S7 Guidelines.
 
The system is commonly used in airway hyper-reactivity studieswhere, in addition to changes in ventilatory parameters, valuable data can obtained 
by quantifying changes in the shape of the respiratory waveform, e.g., Penh. However, it should be noted that when bronchoconstriction is present, 
the respiratory signal is dominated by the effects of gas compression and therefore exact measures of tidal volume can not be determined.
 


Parameters Measured
· Breathing frequency
· Tidal volume (during normal breathing)
· Minute volume
· Penh (enhanced pause)
· Inspiration time
· Expiration time
· Peak inspiratory flow
· Peak expiratory flow
· Explanation and more parameters
 

Features
· Non-invasive
· Real time tidal volume measurement using multiple compensation factors (e.g. Epstein & Epstein, Drorbaugh & Fenn)
· Real time environmental monitoring (atmospheric pressure, temperature, humidity)
· Subject is unrestrained and conscious
· No anaesthesia
· Range of species including guinea pigs, rats and mice
· Chronic and long term use
· Measurement during aerosol challenge
·Up to sixteen animals measured simultaneously
· Optional body temperature measurement through telemetry
 
Uses
· Airway hyper-reactivity models
· Late phase response studies
· Chronic studies
· Drug screening
· Toxicology

参考文献：

[1]. McGonigal, R., et al., Schwann cell nodal membrane disruption triggers bystander axonal degeneration in a Guillain-Barré syndrome mouse model. The Journal of clinical investigation, 2022. 132(14).

 [2]. Aguilar, K., et al., Microglial response promotes neurodegeneration in the Ndufs4 KO mouse model of Leigh syndrome. Glia, 2022. 70(11): p. 2032-2044.

 [3]. Li, J., et al., ActRIIB: ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders. The Journal of Clinical Investigation, 2021. 131(4).

 [4]. Saunders, S.P., et al., Dysregulated skin barrier function in Tmem79 mutant mice promotes IL‐17A‐dependent spontaneous skin and lung inflammation. Allergy, 2020. 75(12): p. 3216-3227.

 [5]. Uchiyama, M., et al., O2-dependent protein internalization underlies astrocytic sensing of acute hypoxia by restricting multimodal TRPA1 channel responses. Current Biology, 2020. 30(17): p. 3378-3396. e7.

 [6]. Bolea, I., et al., Defined neuronal populations drive fatal phenotype in a mouse model of Leigh syndrome. Elife, 2019. 8: p. e47163.

 [7]. Kerscher, B., et al., BET bromodomain inhibitor iBET151 impedes human ILC2 activation and prevents experimental allergic lung inflammation. Frontiers in immunology, 2019. 10: p. 678.

 [8]. Li, X., et al., Mesenchymal stem cells alleviate oxidative stress–induced mitochondrial dysfunction in the airways. Journal of Allergy and Clinical Immunology, 2018. 141(5): p. 1634-1645. e5.

 [9]. Saunders, S.P., et al., Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity. Journal of Allergy and Clinical Immunology, 2016. 137(2): p. 482-491.

[10]. McGonigal, R., et al., C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy. Acta neuropathologica communications, 2016. 4(1): p. 1-16.

[11]. Wiegman, C.H., et al., Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease. Journal of Allergy and Clinical Immunology, 2015. 136(3): p. 769-780.

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