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Lung Cancer EpiTect Methyl qPCR Array

人类肺癌甲基化PCR芯片
 

ProductSpeciesTechnologyCat. No.Lung Cancer EpiTect Methyl qPCR ArrayHumanDNA MethylationEAHS-041ZLung Cancer EpiTect Methyl qPCR ArrayMouseDNA MethylationEAMM-041ZLung Cancer EpiTect Methyl qPCR ArrayRatDNA MethylationEARN-041Z

The Human Lung Cancer EpiTect Methyl II Signature PCR Array profiles the methylation statusof 22 tumor suppressor gene promoters whose hypermethylation has been reported in the literature to occur frequently in a variety of lung tumors. Profiling tumor samples with these arrays may help correlate CpG island methylation status with biological phenotypes. The results may also provide insights into the molecular mechanisms and biological pathways behind lung cancer development and progression, as well as its pathology. With a simple restriction enzyme digestion and real-time PCR, research studies can analyze the methylation status of 22 different lung cancer genes with this DNA methylation PCR array.
Both 96-well and 384-well ( 4 X 96 ) formats are available.
The EpiTect Methyl II PCR Arrays use the MethylScreen™ Technology provided under license from Orion Genomics, LLC.
人类肺癌甲基化PCR芯片用于研究文献已报道在各种各样的肺脏肿瘤中经常发生甲基化的22个肿瘤抑制基因的启动子甲基化状态。利用这些芯片分析细胞或新鲜组织基因组DNA样本有助于关联CpG岛甲基化状态与生物表型。结果还可以洞察肺癌发育和进程,及其病理背后的分子机制和生物学通路。利用这个芯片，通过简单的限制性内切酶消化和实时定量PCR，就可以研究分析22个不同肝癌基因的启动子甲基化状态。
 
包括96-孔板和384-孔板( 4 X 96 )。
Angiogenesis: EP300.
Apoptosis & Anti-Apoptosis: CDKN1B, CDKN2A, FHIT, PYCARD (TMS1/ASC), TNFRSF10D.
Cell Adhesion & Migration: CDH1, DLC1, OPCML (aOBCAM), RELN.
Cell Cycle, Growth, Differentiation & Development: CCND2 (Cyclin D2), CDKN1A, CDKN1B (p27KIP1), CDKN2A, DLC1, EP300, FHIT, RASSF1, WT1.
Cytokine Receptor: TNFRSF10D.
Cytokine Signaling Inhibitor: SOCS1.
DNA Damage Repair: CDKN1A, MSH2, MSH3, RASSF1.
Drug Metabolism: GSTP1.
Extracellular Matrix Remodeling: RELN.
Histidine Triad Gene Family: FHIT.
Inflammation: PYCARD (TMS1/ASC).
Oncogene: E2F1.
Transcription Factors: E2F1, EP300, RUNX3, WT1, EP300.
Tumor Suppressor Gene Candidates: DLEC1, CDKN1A, CDKN2A, E2F1, MSH2, MSH3, RASSF1, RUNX3.
WNT Signaling Pathway: SFRP2.