Stability of retention time and peak areas is critical for a confident evaluation of chromatographic results and to avoid any misinterpretation. The Vanquish UHPLC system is extremely reproducible in both retention time and peak area reproducibility. The retention time precision provided by the system enables the analyst to deduce any change in retention time to an actual change of the sample structure. As shown, the peak area reproducibility provided by Vanquish will result in a maximal confidence of quantitative result. Consequently, the Vanquish system meets the requirements of demanding peptide mapping analysis.