A simple, rapid, and accurate method without derivatization was developed for the analysis of metoprolol succinate and metoprolol EP impurity A, M, and N using isocratic HILIC chromatography with UV and charged aerosol detection. The HPLC detectors are orthogonal and complimentary in nature and render a more comprehensive analysis of the sample since they can detect both chromophore and non-chromophore species using the configuration described. The integrated Vanquish system provides excellent data quality.