There is considereble interest in botanical supplements due to their purpoted health benefits. Mangosteen (Garcinia mangostanal) is a tropical fruit that is indigenous to Southeast Asia, where it has been historically used to treat abdominal pain, diarrhea, dysentery, inflammation, wound infection, suppuration, and chronic ulcer. Recently mangosteen has been proposed as a homeopathic therapy in the treatment of parkinson's disease. Such therapeutic benefits have been mostly atributed to a unique family of compounds referred to as xanthones that are most abundant in the pericrp of the fruit. The structures of the five major xanthones, including α-mangostin, 3-isomangostin, gartanin, 9-hydroxycalabaxanthone, and 8-desoxygartanin, are presented in Figure 1.