A method was developed on a high selectively triple quadrupole GCMS-TQ8040 system for screening trace levels of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) in foodstuffs and animal feed. Smart MRM technology was employed for method development and GC-MS/MS analysis. The results showed good sensitivity and repeatability for PCDD/Fs at low levels, as well as a good linear response over the required concentration range. The performance on real sample analysis indicated the feasibility of Shimadzu GCMS-TQ8040 system for PCDD/Fs measurement in food and feed, as required by European Union legislation.