This study demonstrates a routine screening of drugs to identify and quantify

potential genotoxic compounds. In this Application Note, we used an Agilent 6545

Q

-

TOF LC/MS system to acquire accurate mass data of samples containing

chlorhexidine as the dr

ug substance. Agilent MassHunter Mass Profi ler

software was used to mine the data and compare different samples to generate

a differential list of compounds. An accurate mass database search against the

differential list identifi ed 4

-

chloroaniline, a

potential genotoxic compound. All

Ions

MS/MS acquisition mode was used to confi rm 4

-

chloroaniline by MS/MS library

matching, and quantify it using external standards. This workfl ow is suitable for

batch

-

to

-

batch sample analysis for detecting and quant

ifying known potential

genotoxic compounds