An important point with such a sample transition is thus the inclusion of a fast and precise autofocus system (such as the LabRAM Piezo 100), so that the sample surface will remain in the sampling position throughout an experiment and provide optimum spectroscopic results throughout.

So, but the use of a vapour pressure cell, it is possible through the application of Raman microscopy to follow the gain and loss of water molecules within a crystal structure.

In this instance for the morphine salt it was a repeatable and reversible transition.