密闭条件下加热提供一种快速，重现性好和安全的生成格氏试剂的方法。随后格氏反应同传统的加热回流法相比可以在更短的时间内得到目标产物。

Efficient Grignard Reaction under Sealed Vessel Conditions The Grignard reaction is a powerful, frequently used organometallic transformation to add important structural motifs to carbonyl compounds resulting in secondary or tertiary alcohols. Since usually the low boiling THF is used as a solvent, closed vessel conditions and elevated temperatures can significantly enhance the reaction. This is best done in a conventional synthesis reactor.