The search for new and validated biomarkers is of particular interest in clinical areas like oncology or neurology. As lipids play an important role in many diseases, the area of lipidomics has become central for clinical research.

Introduction

While commonly an in-depth oriented approach to ID as many lipids as possible is applied, clinically-oriented projects demand a high throughput for large sample cohorts. Therefore, a short cycle time per sample is necessary to realize research projects with hundreds or even thousands of samples in a reasonable time frame. To enable this, the analytical instrumentation needs to deliver an uncompromised high data quality at high acquisition speeds. This is realized by the PASEF (Parallel Accumulation Serial Fragmentation) acquisition mode on the timsTOF Pro system.