Abstract:

　　The analysis of toxaphenes still is challenging, not limited to the almost impossible chromatographic separation of the vast amount of isomers, the injection technique as well as the ionization performance have a great influence over reproducibility, linearity and sensitivity. High resolution GC/MS offers the potential for a sensitive analysis providing the selectivity to overcome limiting interferences with matrix components as well as possible coelutions with other xenobiotica.

　　Instrument：

　　DFS高分辨双聚焦磁质谱

　　Conclusion：

　　The chromatography conditions using PTV cold injection technique have successfully been applied to avoid thermal degradation even of the labile P62 congener. Negative chemical ionization with the DFS High Resolution GC/MS has been shown to provide consistent ionization with high response on molecular ions of highest response and specificity. The quantitative calibrations show excellent linearity down to the low fg range with estimated LOQs in the sub fg range.