Introduction

　　A method was developed for the analysis of volatile organic compounds (VOCs) with the Thermo Scientific ISQ single quadrupole GC-MS using quality control requirements based on United States Environmental Protection Agency (EPA) methodologies. This requires integration of a range of instrumentation, from the sample introduction system to the gas chromatograph and mass spectrometer, to the software for data interpretation,analysis and reporting.1 While the overall process of analyzing VOC is a mature technique, there are continuous innovations that allow laboratories to meet lower detection limits and analyze new compounds to comply with changing regulations, with higher throughput and improved quality.