利用同位素质谱的高分辨率分离精确质量鉴定两个共流出的管制药物

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方案摘要

前言

Nandrolone and Clenbuterol are Class C anabolic agents prohibited by the International Olympic Committee, and are routinely monitored in biological samples by human doping control laboratories. Nandrolone, used synegeristically with Clenbuterol, could maximize muscle tissue performance in athletes.

Clenbuterol is a beta-2-adrenergic agonist, which is an effective bronchodilator drug used for the treatment of human asthma. Clenbuterol relieves bronchial airway smooth muscle contractions caused by Chronic Obstructive Pulmonary Disease (COPD) and allergy-induced respiratory distress.

Nandrolone (Nortestosterone) is a steroid occurring naturally in the human body that has anabolic muscle growth stimulant properties. It metabolizes to 19-norandrosterone (3α-hydroxy-5α-estran-17-one, Figure 2) and 19-noretiocholanolone (3α-hydroxy-5β-estran-17-one), and urinary levels of 19-norandrosterone greater than 2 ng/mL indicates the administration of the steroid.

仪器

Finnigan TSQ Quantum Ultra with Accurate Mass option

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