前言：

　　LC-MS/MS has become more accepted as the tool for quantitative analysis of drugs in forensic toxicology laboratories. This technique enables simultaneous detection of multiple analytes of interests and is compatible with a simple “dilute-and-shoot” sample preparation method for urine samples.

仪器：

Thermo Scientific TSQ Quantum mass spectrometer

结论：

　　The developed method provides a simple, fast, and sensitive way for forensic toxicology labs to simultaneously quantify 43 drugs of abuse, including pain management drugs, in human urine by LC-MS/MS. The method provided LLOQ values of 2–20 ng/mL for 42 of the 43 drugs, and was linear to 1000 ng/mL. Minimal ion suppression and no carryover were observed in matrix samples. At the LLOQ, the accuracy ranged between 89.9% and 118.4%. Method precision ranged between 1.1% and 10.9% at low and high QC samples.